CSIRO Waite Campus Seminar: Prof. Dan Szymanski
Nov 20, 4:00 pm
The following seminar will take place at 4:00pm on Wednesday 20th November in the CSIRO Building 1 Seminar Room, gate 4 Waite Road, Urrbrae.
Systems-level analyses of protein complex phenotypes using label free proteomics and protein correlation profiling
Prof. Dan Szymanski | Botany and Plant Pathology, Purdue University USA | CSIRO McMaster Fellow
Protein complexes are fundamentally important for the viability and robustness of living systems. They provide specificity and feedback control in signaling cascades, assemble molecular machines that perform complicated mechanical tasks, control metabolic flux, and allow systems-level integration of cellular pathways. Our lab is developing label-free proteomic methods to analyze the assembly status, composition, localization, and dynamics of endogenous protein complexes in plant organs, tissues, and cells. The method requires biochemical fractionations, reproducible high resolution protein mass spectrometry, a well-annotated proteome, and automated data mining procedures. This seminar will describe the use of label-free protein correlation profiling to provide useful systems-level data on the composition, dynamics, and evolution of protein complexes.
(McBride et al., A Label-Free Mass Spectrometry Method to Predict Endogenous Protein Complex Composition, Mol. Cell. Prot. 2019)
ABOUT THE SPEAKER
Dan Szymanski is a cell biologist and biochemist at Purdue University, USA. His work focuses on using experimental and computational approaches to analyze morphogenesis at the spatial scales of cells, tissues, and organs. His group also develops proteomic strategies for the high throughput analysis of endogenous protein complexes.
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